Bio-Absorbable Magnesium Scaffolds for Bone Regeneration
Jenkins S., Lee K. · Biomaterials
Abstract
Evaluating the degradation rate and osteoconductivity of novel magnesium alloy scaffolds in critical-sized defects.
Methodology
Porous scaffolds using high-purity Mg-Zn-Y-Zr alloys were fabricated via selective laser melting (SLM) with structured micro-porosity (70% porosity, 400µm pore size). The scaffolds were evaluated in-vitro under simulated body fluid and in-vivo within rabbit distal femoral defects.
Findings
In-vivo radiological and histological analysis showed complete osseointegration within 12 weeks. Scaffold degradation rates perfectly matched the rate of new bone tissue deposition, maintaining critical load-bearing mechanical integrity during the entire bone-bridge healing window.
Conclusion
Bio-absorbable magnesium alloy scaffolds provide excellent osteoconductivity and high immediate structural stability, representing a viable biological alternative to permanent titanium hardware.